| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-12-25 18:00 | Racing de Ferrol | SD Huesca | 0:2 |
| 02-12-25 18:00 | CD Numancia | RCD Mallorca | 2:3 |
| 02-12-25 18:00 | CD Ebro | CA Osasuna | 3:5 |
| 02-12-25 18:00 | Club Portugalete | Deportivo Alavés | 0:3 |
| 02-12-25 19:00 | CD Guadalajara | AD Ceuta FC | 1:0 |
| 02-12-25 20:00 | CD Artistico Navalcarnero | FC Getafe | 2:3a.p. |
| 03-12-25 19:00 | Real Murcia C. F. | FC Cádiz | 3:2 |
| 03-12-25 19:00 | CD Mirandés | Sporting Gijón | 0:2 |
| 03-12-25 19:00 | CyD Leonesa | Andorra CF | 4:2 |
| 03-12-25 19:00 | CD Eldense | UD Almeria | 2:1 |
| 03-12-25 19:00 | CF Talavera de la Reina | FC Málaga | 2:1 |
| 03-12-25 20:00 | CF Pontevedra | SD Eibar | 0:3 |
| 03-12-25 20:00 | CF Ourense | FC Girona | 2:1 |
| 03-12-25 20:00 | CD Cieza | UD Levante | 0:1 |
| 03-12-25 20:00 | Torrent CF | Real Betis Sevilla | 1:4 |
| 03-12-25 20:00 | CF Reús Deportiu | Real Sociedad | 0:2 |
| 03-12-25 20:00 | CD Quintanar del Rey | FC Elche | 1:2a.p. |
| 03-12-25 20:00 | CA Antoniano | FC Villarreal | 4:6a.pen. |
| 04-12-25 18:00 | Real Ávila CF | Rayo Vallecano | 1:2a.p. |
| 04-12-25 18:00 | CD Leganés | Albacete Balompie | 1:2 |
| 04-12-25 18:00 | CD Sabadell | Deportivo La Coruña | 0:2 |
| 04-12-25 18:00 | Atletico Baleares | Espanyol Barcelona | 1:0 |
| 04-12-25 19:00 | SD Ponferradina | Racing Santander | 1:2a.p. |
| 04-12-25 20:00 | FC Cartagena | FC Valencia | 1:2a.p. |
| 04-12-25 20:00 | Real Zaragoza | Burgos CF | 0:1a.p. |
| 04-12-25 20:00 | UE Sant Andreu | Celta Vigo | 7:8a.pen. |
| 04-12-25 20:00 | CD Extremadura | FC Sevilla | 1:2 |
| 04-12-25 21:00 | CD Teneriffa | FC Granada | 0:1 |